Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Isonipecotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.85 |
| ▸ | GABRP | O00591 | 1/20 | 0.85 |
| ▸ | GABRD | O14764 | 1/20 | 0.85 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.85 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.85 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.85 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.85 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.85 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.85 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.85 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.85 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.85 |
| ▸ | GABRE | P78334 | 1/20 | 0.85 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.85 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.85 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.85 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.85 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.85 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isonipecotic Acid SCHEMBL104297 | 0.92 | — | — | |
| Isonipecotic Acid SCHEMBL2027408 | 0.92 | TSHR (1.00) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL28266161 | 0.90 | TSHR (0.85) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL23043998 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL1703706 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL30060745 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL5035880 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL6122239 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL2560208 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL31602943 | 0.90 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120131905-A | Method for improving stability of illegal preparation of diligent acetate | 苏州天马医药集团天吉生物制药有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-109280075-A | Peptide amide class compound and preparation method thereof and purposes in medicine | 四川海思科制药有限公司 | 2019-01-29 | — | — | CN | disclosed |
| EP-0885213-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0885213-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997025323-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-17 | — | — | WO | disclosed |