Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | VNN1 | O95497 | 6/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F13A1 | P00488 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575737 | 0.77 | TMEM97 (0.49) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29637090 | 0.74 | RAB9A (0.50) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL31141609 | 0.74 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL31141710 | 0.74 | HDAC3 (0.80) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL31141641 | 0.74 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL31141667 | 0.74 | HDAC3 (0.64) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL2384951 | 0.74 | STAT6 (0.60) | STAT6ULK1 | |
| SCHEMBL31141722 | 0.73 | HDAC3 (0.79) | STAT6HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4730507 | 0.71 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL31141715 | 0.71 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC6VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188457-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF GLIOBLASTOMA BY INHIBITION OF THE TFPI2-CD51-STAT6 SIGNALING AXIS | NORTHWESTERN UNIVERSITY | 2025-06-12 | — | — | US | disclosed |
| US-11414410-B2 | Inhibitors of protein kinases | ALEXION PHARMACEUTICALS, INC. (US) | 2022-08-16 | — | — | US | disclosed |
| US-20200239458-A1 | INHIBITORS OF PROTEIN KINASES | ALEXION PHARMACEUTICALS, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10385080-B2 | STAT6 inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180222931-A1 | STAT6 INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180186783-A1 | INHIBITORS OF PROTEIN KINASES | ALEXION PHARMACEUTICALS, INC. | 2018-07-05 | — | — | US | disclosed |
| US-9868729-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-9765099-B2 | STAT6 inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-19 | — | — | US | disclosed |
| EP-2321283-B1 | 2,6-DIAMINO-PYRIMIDIN-5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-20160145279-A1 | STAT6 INHIBITORS | BAYLOR COLLEGE OF MEDICINE (US) | 2016-05-26 | — | — | US | disclosed |
| EP-2323993-B1 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2015-06-03 | — | — | EP | disclosed |
| US-20150094298-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. | 2015-04-02 | — | — | US | disclosed |
| US-8937070-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2015-01-20 | — | — | US | disclosed |
| US-20140031361-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. | 2014-01-30 | — | — | US | disclosed |
| US-8501944-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8138339-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385080-B2 | STAT6 inhibitors | STAT6, STAT3, STAT1 | STAT6 1/4885HDAC3 131/4885HDAC1 164/4885 |
| US-20160145279-A1 | STAT6 INHIBITORS | STAT6, STAT3, STAT1 | STAT6 1/4885HDAC3 131/4885HDAC1 164/4885 |
| US-20180222931-A1 | STAT6 INHIBITORS | STAT6, STAT3, STAT1 | STAT6 1/4885HDAC3 131/4885HDAC1 164/4885 |
| US-20200239458-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | STAT6 319/4885HDAC3 3532/4885HDAC1 3946/4885 |
| US-20180186783-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | STAT6 319/4885HDAC3 3532/4885HDAC1 3946/4885 |
| US-11414410-B2 | Inhibitors of protein kinases | MAP3K1, MAP3K20, MAP3K2 | STAT6 765/4885HDAC3 700/4885HDAC1 479/4885 |
| US-20140031361-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | STAT6 319/4885HDAC3 3532/4885HDAC1 3946/4885 |
| US-20150094298-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | STAT6 319/4885HDAC3 3532/4885HDAC1 3946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.