Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 16/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.70 |
| ▸ | GABRG2 | P18507 | 15/20 | 0.70 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.70 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.70 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | GMNN | O75496 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | APEX1 | P27695 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378648 | 0.87 | GABRA1 (0.84) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL7381592 | 0.85 | GABRA1 (0.66) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL10905251 | 0.85 | GABRA1 (0.79) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL7386571 | 0.84 | NPC1 (0.53) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL7384927 | 0.84 | GABRA1 (0.68) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL10627998 | 0.83 | GABRA1 (0.74) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL10906474 | 0.83 | GABRA1 (0.74) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL29369769 | 0.82 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL472510 | 0.82 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| SCHEMBL10903537 | 0.82 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010077-A | Tranquilizers | A/S FERROSAN (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0030254-B1 | BETA-CARBOLIN-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR THERAPEUTICAL USE | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-10-31 | — | — | EP | disclosed |
| US-4371536-A | TRANQUILIZERS | A/S FERROSAN (DK) | 1983-02-01 | — | — | US | disclosed |
| EP-0030254-A1 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-06-17 | — | — | EP | disclosed |