Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAS1 | P04201 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.41 |
| ▸ | EDNRA | P25101 | 4/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383678 | 0.91 | MAS1 (0.55) | MAS1AGTR2AGTR1 | |
| SCHEMBL3975298 | 0.89 | AGTR2 (0.48) | MAS1AGTR2AGTR1 | |
| SCHEMBL6185055 | 0.87 | MAS1 (0.46) | MAS1AGTR2EDNRAAGTR1 | |
| SCHEMBL4106849 | 0.85 | MAS1 (0.60) | MAS1AGTR2EDNRAAGTR1 | |
| SCHEMBL3902365 | 0.82 | MAS1 (0.55) | MAS1AGTR2AGTR1 | |
| SCHEMBL3903957 | 0.82 | MAS1 (0.56) | MAS1AGTR2AGTR1 | |
| SCHEMBL4106426 | 0.81 | MAS1 (0.59) | MAS1AGTR2EDNRAAGTR1 | |
| SCHEMBL4110594 | 0.79 | MAS1 (0.58) | MAS1AGTR2EDNRAAGTR1 | |
| SCHEMBL6183402 | 0.78 | MAS1 (0.54) | MAS1AGTR2AGTR1 | |
| SCHEMBL24637548 | 0.77 | AGTR2 (0.61) | MAS1AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185527-A1 | 1-(P-THIENYLBENZYL)-IMIDAZOLES AS ANGIOTENSIN-(1-7) RECEPTOR AGONISTS, METHOD FOR THE PRODUCTION AND THE UTILIZATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS | Aventis Pharma Deutschland GmbH (DE) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000068226-A1 | 1-(P-THIENYLBENZYL)-IMIDAZOLES AS ANGIOTENSIN-(1-7) RECEPTOR AGONISTS, METHOD FOR THE PRODUCTION AND THE UTILIZATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-16 | — | — | WO | disclosed |