Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 7/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 8/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | SCN1A | P35498 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377827 | 0.91 | CACNA1C (0.63) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7383448 | 0.90 | CACNA1C (0.56) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7385085 | 0.89 | CACNA1C (0.56) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7376070 | 0.88 | ADORA3 (0.55) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7378269 | 0.86 | CACNA1C (0.56) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7384823 | 0.86 | CACNA1C (0.53) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL10727811 | 0.85 | ADORA3 (0.74) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL7380358 | 0.84 | CACNA1D (0.52) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL10723440 | 0.81 | CACNA1D (0.57) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S | |
| SCHEMBL29810716 | 0.81 | CACNA1C (0.77) | CACNA1CCACNA1BCACNA1DCACNA1FCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |