⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105840 | 1.00 | — | — | |
| SCHEMBL8703428 | 0.97 | — | — | |
| SCHEMBL18170386 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL23407282 | 0.88 | — | — | |
| SCHEMBL29190753 | 0.84 | — | — | |
| SCHEMBL22093402 | 0.78 | — | — | |
| SCHEMBL15502312 | 0.74 | MC4R (0.31) | — | |
| SCHEMBL2181453 | 0.74 | — | — | |
| SCHEMBL8702181 | 0.74 | ALDH1A1 (0.32) | — | |
| SCHEMBL12449195 | 0.72 | SMN1; SMN2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138342-B2 | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds | High Point Pharmacueticals, LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090105289-A1 | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds | NOVO NORDISK A/S (DK) | 2009-04-23 | — | — | US | disclosed |
| EP-1802623-A1 | 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE SPIRO COMPOUNDS | Novo Nordisk A/S (DK) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040329-A1 | 1 IBETA- HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE SPIRO COMPOUNDS | NOVO NORDISK A/S (DK) | 2006-04-20 | — | — | WO | disclosed |