Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.30 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389329 | 0.85 | KCNH2 (0.50) | KCNH2DRD2DRD3KDM1AKCNE1 | |
| SCHEMBL9039873 | 0.84 | KCNH2 (0.50) | KCNH2DRD2DRD3PGRHTR2A | |
| SCHEMBL7384445 | 0.83 | KCNH2 (0.48) | KCNH2DRD2DRD3 | |
| SCHEMBL7388072 | 0.82 | KCNH2 (0.48) | KCNH2DRD2DRD3PGRHTR2A | |
| Hydrochloric Acid SCHEMBL7359212 | 0.81 | KCNH2 (0.48) | KCNH2DRD2DRD3PGRBRD4 | |
| Hydrochloric Acid SCHEMBL8832236 | 0.81 | KCNH2 (0.46) | KCNH2DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8803796 | 0.73 | KCNH2 (0.38) | KCNH2HTR2AHTR2CMEN1CYP1A2 | |
| SCHEMBL7383236 | 0.72 | KCNH2 (0.83) | KCNH2DRD2DRD3PGRHTR2A | |
| SCHEMBL8832002 | 0.72 | KCNH2 (0.83) | KCNH2DRD2DRD3PGRHTR2A | |
| Hydrochloric Acid SCHEMBL8831816 | 0.72 | KCNH2 (0.82) | KCNH2DRD2DRD3PGRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683782-A4 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS. | MERCK & CO INC (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0683782-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO. INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1995001335-A1 | NOVEL SPIROCYCLES | MERCK & CO., INC. (US) | 1995-01-12 | — | — | WO | disclosed |
| WO-1994018204-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |