Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9041198 | 0.84 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL7388072 | 0.84 | KCNH2 (0.48) | KCNH2DRD2DRD3BRD4HTR2A | |
| SCHEMBL7383232 | 0.84 | KCNH2 (0.53) | KCNH2DRD2DRD3BRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7359212 | 0.84 | KCNH2 (0.48) | KCNH2DRD2DRD3BRD4PGR | |
| SCHEMBL7389329 | 0.79 | KCNH2 (0.50) | KCNH2DRD2DRD3KDM1A | |
| SCHEMBL7384445 | 0.77 | KCNH2 (0.48) | KCNH2DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8832236 | 0.75 | KCNH2 (0.46) | KCNH2DRD2DRD3 | |
| SCHEMBL8563993 | 0.73 | KCNH2 (0.77) | KCNH2DRD2HTR2A | |
| SCHEMBL8831674 | 0.73 | KCNH2 (0.77) | KCNH2DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8566121 | 0.73 | KCNH2 (0.76) | KCNH2DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683782-A4 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS. | MERCK & CO INC (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0683782-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO. INC. (US) | 1995-11-29 | — | — | EP | disclosed |
| WO-1994018204-A1 | SPIRO (2H-1-BENZOPYRAN-2, 4' PIPERIDINE) CLASS III ANTIARRHYTHMICS | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |