Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 2/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19815565 | 0.98 | HDAC8 (0.46) | HDAC8HDAC6HTR2CHTR2BPRCP | |
| SCHEMBL3806378 | 0.98 | HDAC8 (0.46) | HDAC8HDAC6HTR2CHTR2BPRCP | |
| SCHEMBL29572383 | 0.98 | HDAC8 (0.46) | HDAC8HDAC6HTR2CHTR2BPRCP | |
| SCHEMBL443064 | 0.91 | — | — | |
| SCHEMBL6160852 | 0.91 | — | — | |
| SCHEMBL15962430 | 0.83 | PRCP (0.46) | HTR2CHTR2BPRCPULK1DPP7 | |
| SCHEMBL29789556 | 0.82 | PRCP (0.46) | HTR2CHTR2BPRCPULK1DPP7 | |
| SCHEMBL9824982 | 0.80 | EPHX1 (0.48) | HTR2CHTR2BPRCPCYP3A4 | |
| SCHEMBL13306379 | 0.79 | PRCP (0.47) | HTR2CHTR2BPRCPULK1DPP7 | |
| SCHEMBL22221409 | 0.79 | PRCP (0.47) | HTR2CHTR2BPRCPULK1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | claimed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | claimed |