Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 8/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | PDE1A | P54750 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128167 | 0.94 | PDE4B (0.70) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL7176867 | 0.91 | PDE4B (0.66) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL6799815 | 0.88 | PDE4B (0.71) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL14003536 | 0.88 | PDE4B (0.61) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL7364684 | 0.87 | PDE4D (0.60) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL16544966 | 0.85 | PDE4B (0.67) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL23901634 | 0.84 | PDE4B (0.57) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL8888177 | 0.84 | CYP2D6 (0.61) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL16544973 | 0.84 | MAPT (0.59) | PDE4BPDE4DMAPK14PDE4APDE4C | |
| SCHEMBL15030530 | 0.83 | PDE4B (0.50) | PDE4BPDE4DMAPK14PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021202600-A1 | SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-10-07 | — | — | WO | disclosed |
| EP-0889879-B1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6248743-B1 | ANTITHROMBOTIC AGENTS EFFECTIVE TO INHIBIT THE PRODUCTION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | TANABE SEIYAKU CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| EP-0889879-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036864-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |