Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.60 |
| ▸ | PDE4A | P27815 | 10/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16544973 | 0.97 | MAPT (0.59) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL5309884 | 0.94 | PDE4D (0.67) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL16544967 | 0.94 | MAPT (0.62) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL8888177 | 0.89 | CYP2D6 (0.61) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL18031253 | 0.88 | MAPT (0.53) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL15595474 | 0.87 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CMAPT | |
| SCHEMBL6799815 | 0.87 | PDE4B (0.71) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL7384113 | 0.87 | PDE4B (0.62) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6799389 | 0.86 | HSD17B2 (0.58) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL20021951 | 0.85 | PDE4B (0.54) | PDE4DPDE4BPDE4APDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| US-5563143-A | ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISORDERS | PFIZER INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0706795-A2 | Catechol diether compounds as inhibitors of TNF release | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |