Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 5/20 | 0.34 |
| ▸ | GRN | P28799 | 2/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374947 | 0.92 | ACE2 (0.39) | ACE2ACENTSR1GRNSORT1 | |
| SCHEMBL7375023 | 0.85 | ACE2 (0.39) | ACE2ACENTSR1GRNSORT1 | |
| SCHEMBL3715236 | 0.85 | ACE2 (0.39) | ACE2ACENTSR1GRNSORT1 | |
| SCHEMBL7383288 | 0.85 | ACE2 (0.41) | ACE2ACENTSR1GRNSORT1 | |
| SCHEMBL7375034 | 0.85 | ANPEP (0.43) | ACE2ACENTSR1GRNSORT1 | |
| SCHEMBL7398069 | 0.85 | P2RY14 (0.38) | ACE2ACEGRNSORT1 | |
| SCHEMBL7382228 | 0.84 | ACE2 (0.43) | ACE2ACEGRNSORT1 | |
| SCHEMBL3707154 | 0.83 | CD274 (0.42) | ACE2ACE | |
| SCHEMBL3714339 | 0.83 | ACE2 (0.43) | ACE2ACENTSR1 | |
| SCHEMBL7389292 | 0.82 | ALDH1A1 (0.42) | ACE2ACENTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543120-A | — | — | 2002-12-17 | — | — | JP | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| EP-1183019-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2002-03-06 | — | — | EP | claimed |
| WO-2000066104-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | claimed |
| WO-2000066104-A9 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARM INC (US) | 2002-08-29 | — | — | WO | disclosed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |