Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506053 | 1.00 | ALOX15 (0.33) | ALOX15BLMPMP22KMT2ANOS2 | |
| SCHEMBL16165635 | 0.78 | TP53 (0.33) | — | |
| SCHEMBL5534952 | 0.76 | HIF1A (0.34) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9872062 | 0.74 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27778494 | 0.74 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9872066 | 0.74 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22259868 | 0.74 | — | — | |
| SCHEMBL22260390 | 0.74 | — | — | |
| SCHEMBL22260410 | 0.74 | — | — | |
| SCHEMBL22259899 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338600-B1 | PROCESS FOR THE PREPARATION OF PROLINOLAMIDE DERIVATIVES | MERCK & CO. INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5087703-A | 2-Methyl-4-hydroxy-5-protected hydroxy-hept-6-en-prolinolamides | MERCK & CO., INC. (US) | 1992-02-11 | — | — | US | disclosed |
| EP-0338600-A1 | Process for the preparation of prolinolamide derivatives | MERCK & CO. INC. (US) | 1989-10-25 | — | — | EP | disclosed |