Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.57 |
| ▸ | PGC | P20142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382612 | 0.87 | REN (0.58) | RENPGC | |
| SCHEMBL9876239 | 0.87 | REN (0.64) | REN | |
| SCHEMBL10763189 | 0.87 | REN (0.64) | REN | |
| SCHEMBL9876304 | 0.87 | REN (0.64) | REN | |
| SCHEMBL10763181 | 0.87 | REN (0.64) | REN | |
| SCHEMBL9876303 | 0.87 | REN (0.64) | REN | |
| SCHEMBL9876238 | 0.87 | REN (0.64) | REN | |
| SCHEMBL10540148 | 0.86 | REN (0.60) | RENPGC | |
| SCHEMBL9876595 | 0.86 | REN (0.61) | REN | |
| SCHEMBL9876339 | 0.86 | REN (0.63) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114925-A | Renin inhibitors containing the 2-[[(2R,3S)-3-amino-4-cyclohexyl-2-hydroxy-1-butyl]thio)alkanoyl moiety and the corresponding sulfoxide and sulfone derivatives | MERCK & CO., INC. (US) | 1992-05-19 | — | — | US | disclosed |