Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385157 | 1.00 | HDAC8 (0.47) | HDAC8CREBBPDDB1CRBNBRD4 | |
| SCHEMBL24491239 | 0.85 | TACR2 (0.46) | HDAC8 | |
| SCHEMBL3220126 | 0.83 | HDAC8 (0.41) | HDAC8DDB1CRBNPOLB | |
| SCHEMBL8270781 | 0.79 | CTSD (0.59) | HDAC8DDB1CRBNPOLBGBA1 | |
| SCHEMBL2132646 | 0.79 | CTSD (0.59) | HDAC8DDB1CRBNPOLBGBA1 | |
| SCHEMBL19419777 | 0.79 | CTSD (0.59) | HDAC8DDB1CRBNPOLBGBA1 | |
| SCHEMBL14646624 | 0.78 | POLB (0.51) | HDAC8DDB1CRBNPOLBGBA1 | |
| SCHEMBL14646638 | 0.78 | POLB (0.51) | HDAC8DDB1CRBNPOLBGBA1 | |
| SCHEMBL4989773 | 0.77 | MEN1 (0.47) | CREBBPBRD4 | |
| SCHEMBL877508 | 0.76 | HDAC6 (0.48) | HDAC8DDB1CRBNPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338861-A | Cleaving lactam N-carboxylate or lactim O-carboxylate with elimination of carbon dioxide by heating in gas or liquid phase | BAYER AKTIENGESELLSCHAFT (DE) | 1994-08-16 | — | — | US | claimed |
| EP-1021405-B1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM CA LTD (CA) | 2002-09-25 | — | — | EP | disclosed |
| US-6242439-B1 | Azetidinone derivatives for the treatment of HCMV infections | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2001-06-05 | — | — | US | disclosed |
| EP-1021405-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999018072-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1999-04-15 | — | — | WO | disclosed |
| EP-0531673-B1 | Process for the preparation of N-substituted lactams | BAYER AG (DE) | 1996-09-11 | — | — | EP | disclosed |
| US-5338861-A | Cleaving lactam N-carboxylate or lactim O-carboxylate with elimination of carbon dioxide by heating in gas or liquid phase | BAYER AKTIENGESELLSCHAFT (DE) | 1994-08-16 | — | — | US | disclosed |
| EP-0531673-A1 | Process for the preparation of N-substituted lactams | BAYER AG (DE) | 1993-03-17 | — | — | EP | disclosed |