Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 12/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381202 | 0.90 | PKM (0.54) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL8134779 | 0.83 | PKM (0.57) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL12963477 | 0.83 | PKM (0.57) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL14310598 | 0.82 | PKM (0.59) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL8350149 | 0.79 | PKM (0.52) | PKMPLK1KDM4ESYKTAS2R14 | |
| SCHEMBL13879819 | 0.79 | PKM (0.52) | PKMKDM4ESYKTDP1MAPT | |
| SCHEMBL12932877 | 0.77 | HRH4 (0.50) | PKMPLK1KDM4ESYKGAA | |
| SCHEMBL15353082 | 0.75 | HRH4 (0.50) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL6636158 | 0.75 | PKM (0.52) | PKMPLK1KDM4ESYKTDP1 | |
| SCHEMBL17700454 | 0.74 | IDH1 (0.57) | PKMSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019386-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998038179-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-09-03 | — | — | WO | disclosed |