Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 5/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | C1S | P09871 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373625 | 0.88 | MEN1 (0.31) | — | |
| SCHEMBL7380233 | 0.85 | PLAU (0.39) | — | |
| Hydrochloric Acid SCHEMBL7379848 | 0.84 | PLAU (0.38) | — | |
| Hydrochloric Acid SCHEMBL7386017 | 0.80 | PLAU (0.46) | L3MBTL1 | |
| SCHEMBL6436458 | 0.80 | PLG (0.52) | — | |
| Hydrochloric Acid SCHEMBL7366869 | 0.79 | PLAU (0.41) | — | |
| Hydrochloric Acid SCHEMBL6433178 | 0.79 | PLG (0.51) | — | |
| SCHEMBL6434174 | 0.78 | PLAU (0.50) | — | |
| Hydrochloric Acid SCHEMBL6437764 | 0.77 | PLAU (0.49) | — | |
| Hydrochloric Acid SCHEMBL7376136 | 0.77 | PLAU (0.48) | FEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |