Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | MME | P08473 | 2/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | CPA1 | P15085 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322093 | 0.83 | CTNNB1 (0.60) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL2386216 | 0.81 | MAPT (0.46) | MAPTALDH1A1PPARGPPARAMMP9 | |
| SCHEMBL2673397 | 0.81 | MAPT (0.46) | MAPTALDH1A1PPARGPPARAL3MBTL1 | |
| SCHEMBL4330321 | 0.81 | MAPT (0.46) | MMEACECPA1ACE2MAPT | |
| SCHEMBL2673224 | 0.80 | ALDH1A1 (0.46) | MAPTALDH1A1PPARAKMT2A | |
| SCHEMBL5972400 | 0.80 | MAPT (0.45) | MMEACECPA1ACE2MAPT | |
| SCHEMBL7272663 | 0.80 | CTNNB1 (0.75) | CTNNB1MMEACECPA1ACE2 | |
| SCHEMBL335398 | 0.79 | MAPT (0.51) | MMEACECPA1ACE2MAPT | |
| SCHEMBL2672961 | 0.78 | MAPT (0.43) | TDP1MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1030510 | 0.78 | MAPT (0.40) | MAPTKDM4EPPARGPPARAMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055466-A | Renin inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |