Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738776 | 1.00 | CFD (0.38) | CFDKCNH2HRH1CYP2D6DPP4 | |
| SCHEMBL739272 | 0.92 | NPY1R (0.36) | CFDKCNH2HRH1CYP2D6MEN1 | |
| SCHEMBL739273 | 0.92 | NPY1R (0.36) | CFDKCNH2HRH1CYP2D6MEN1 | |
| SCHEMBL738703 | 0.90 | TACR1 (0.36) | KCNH2HRH1CYP2D6MEN1KMT2A | |
| SCHEMBL739244 | 0.89 | HRH1 (0.46) | KCNH2HRH1CYP2D6CHRM1CYP3A4 | |
| SCHEMBL739245 | 0.89 | HRH1 (0.46) | KCNH2HRH1CYP2D6CHRM1CYP3A4 | |
| SCHEMBL739776 | 0.89 | HRH1 (0.39) | CFDKCNH2HRH1CYP2D6DPP4 | |
| SCHEMBL739777 | 0.89 | HRH1 (0.39) | CFDKCNH2HRH1CYP2D6DPP4 | |
| SCHEMBL10293032 | 0.87 | PADI4 (0.37) | KCNH2HRH1CYP2D6MEN1KMT2A | |
| SCHEMBL739598 | 0.87 | HRH1 (0.35) | KCNH2HRH1CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |