Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313419 | 0.95 | GRM5 (0.66) | GRM5APPCHEK1 | |
| SCHEMBL1656957 | 0.75 | GRM5 (0.58) | GRM5CHEK1 | |
| SCHEMBL15692608 | 0.72 | GRM5 (0.55) | GRM5APPCHEK1 | |
| SCHEMBL67456 | 0.72 | — | — | |
| SCHEMBL1656880 | 0.69 | TDP1 (0.59) | GRM5CHEK1 | |
| SCHEMBL24075982 | 0.68 | GRM5 (0.54) | GRM5APPCHEK1 | |
| SCHEMBL1656990 | 0.67 | GRM5 (0.52) | GRM5CHEK1 | |
| SCHEMBL1657308 | 0.67 | GRM5 (0.52) | GRM5CHEK1 | |
| SCHEMBL21189528 | 0.66 | GRM5 (0.33) | GRM5 | |
| SCHEMBL15322434 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |