Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.66 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387992 | 0.95 | GRM5 (0.60) | GRM5APPCHEK1 | |
| SCHEMBL1656957 | 0.79 | GRM5 (0.58) | GRM5CHEK1KDM4E | |
| SCHEMBL15692608 | 0.76 | GRM5 (0.55) | GRM5APPCHEK1NPC1ALDH1A1 | |
| SCHEMBL1656880 | 0.73 | TDP1 (0.59) | GRM5CHEK1KDM4EMEN1NPC1 | |
| SCHEMBL24075982 | 0.72 | GRM5 (0.54) | GRM5APPCHEK1KDM4EMEN1 | |
| SCHEMBL1657308 | 0.71 | GRM5 (0.52) | GRM5CHEK1NPC1ALOX15RAB9A | |
| SCHEMBL21189528 | 0.69 | GRM5 (0.33) | GRM5 | |
| SCHEMBL15322434 | 0.69 | — | — | |
| Diphenylacetylene SCHEMBL29188592 | 0.68 | APP (1.00) | GRM5APPKDM4EMEN1NPC1 | |
| Diphenylacetylene SCHEMBL960609 | 0.68 | APP (1.00) | GRM5APPKDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014065411-A1 | SULFONAMIDE DERIVATIVE AS HARMFUL-ORGANISM CONTROL AGENT FOR AGRICULTURAL/HORTICULTURAL USE | 株式会社エス・ディー・エス バイオテック (JP) | 2014-05-01 | — | — | WO | disclosed |
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |