SCHEMBL7388442

SCHEMBL7388442

CCOC(=O)CC(c1ccc(O[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1)c1cc2cc(C#N)ccc2o1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 5/20 0.51
CETP P11597 1/20 0.42
F2 P00734 1/20 0.40
F10 P00742 1/20 0.40
ALK Q9UM73 1/20 0.40
PIK3CD O00329 9/20 0.39
USP30 Q70CQ3 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7388447 0.86 GPR119 (0.49) GPR119CETPF2F10ALK
SCHEMBL7384314 0.85 F10 (0.51) GPR119CETPF2F10ALK
SCHEMBL7385386 0.82 GPR119 (0.49) GPR119CETPF2F10ALK
SCHEMBL7387156 0.82 GPR119 (0.48) GPR119CETPF2F10ALK
SCHEMBL7387569 0.81 GPR119 (0.50) GPR119CETPF2F10ALK
SCHEMBL7387571 0.81 GPR119 (0.50) GPR119CETPF2F10ALK
SCHEMBL7389406 0.80 GPR119 (0.46) GPR119CETPF2F10ALK
SCHEMBL7389231 0.80 GPR119 (0.54) GPR119CETPF2F10ALK
SCHEMBL7385212 0.80 F10 (0.55) GPR119CETPF2F10ALK
SCHEMBL7386795 0.79 GPR119 (0.49) GPR119CETPF2F10ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962695-A ANTICOAGULANT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-10-05 US disclosed
US-5866577-A AN ANTICOAGULANT AGENT DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-02-02 US disclosed
US-5620991-A ANTICOAGULANTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-04-15 US disclosed
US-5576343-A ANTICOAGULANTS; BLOOD-COAGULATION FACTOR X INHIBITORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1996-11-19 US disclosed
EP-0540051-B1 Aromatic amidine derivatives and salts thereof DAIICHI SEIYAKU CO (JP) 1996-04-03 EP disclosed
EP-0540051-A1 Aromatic amidine derivatives and salts thereof DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1993-05-05 EP disclosed