Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 13/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388781 | 0.99 | ALDH1A1 (0.63) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| SCHEMBL6446698 | 0.99 | ALDH1A1 (0.63) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| SCHEMBL6447545 | 0.89 | ALDH1A1 (0.64) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| SCHEMBL2402633 | 0.89 | ALDH1A1 (0.70) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| SCHEMBL6446295 | 0.86 | ALDH1A1 (0.55) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| SCHEMBL6443522 | 0.86 | ALDH1A1 (0.63) | ALDH1A1KMT2ATSHRCYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL6446632 | 0.82 | KMT2A (0.80) | ALDH1A1KMT2ACYP2D6PDE5AKDM4E | |
| SCHEMBL6442764 | 0.81 | KMT2A (0.66) | ALDH1A1KMT2ACYP2D6PDE5AGAA | |
| Hydrochloric Acid SCHEMBL6443518 | 0.81 | KMT2A (0.59) | ALDH1A1KMT2ATSHRCYP2D6PDE5A | |
| SCHEMBL6446145 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KMT2ATSHRCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073658-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999054333-A1 | PYRAZOLOPYRIMIDINONE CGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER INC. (US) | 1999-10-28 | — | — | WO | disclosed |