Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223057 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL3855699 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL9784627 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL1931465 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL9216022 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL9205173 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL3335340 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL6242253 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL183454 | 0.97 | TSHR (0.40) | TSHRTHRBFAAHTRPV1ADH1B | |
| SCHEMBL333838 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410646-A | Torque limiter | JTEKT CORP (JP) | 2009-04-15 | — | — | CN | disclosed |
| CN-1784203-A | Cosmetic composition containing cyclohexane polycarboxylic acid derivative | BASF AG (DE) | 2006-06-07 | — | — | CN | disclosed |
| CN-1205181-C | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUOTS LT (DK) | 2005-06-08 | — | — | CN | disclosed |
| CN-1289323-A | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUOTS LT (DK) | 2001-03-28 | — | — | CN | disclosed |
| EP-1060161-A1 | MATRIX METALLOPROTEINASE INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044989-A1 | MATRIX METALLOPROTEINASE INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 1999-09-10 | — | — | WO | disclosed |
| US-4873235-A | COUPLING KETO ESTER WITH LACTAM; ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4684645-A | GASTROINTESTINAL AND NERVOUS SYSTEM DISORDERS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |
| US-4634716-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1987-01-06 | — | — | US | disclosed |
| US-4626545-A | Amino acid derivatives as enzyme inhibitors | MERCK & CO., INC. (US) | 1986-12-02 | — | — | US | disclosed |
| EP-0166354-A2 | Benzofused lactam compounds and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |
| US-4555503-A | ANGIOTENSIN INHIBITORS | MERCK & CO., INC. (US) | 1985-11-26 | — | — | US | disclosed |