Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389938 | 0.94 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7387691 | 0.90 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7389096 | 0.87 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL7390991 | 0.86 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7391720 | 0.86 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7392541 | 0.86 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7389159 | 0.85 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL7713358 | 0.83 | PDE4A (0.66) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7325310 | 0.82 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CCYP3A4 | |
| SCHEMBL6755365 | 0.81 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780477-A | Trisubstituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | claimed |
| US-5780477-A | Trisubstituted phenyl derivatives and processes for their preparation | CELLTECH THERAPEUTICS, LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |