Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713350 | 0.94 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7715309 | 0.90 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7709539 | 0.86 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7709552 | 0.85 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7709483 | 0.85 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7709498 | 0.84 | PDE4A (0.73) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7709517 | 0.84 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7389933 | 0.83 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7389161 | 0.83 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755361 | 0.82 | PDE4A (0.95) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766670-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2002-03-27 | — | — | EP | claimed |
| EP-0766670-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | claimed |
| WO-1995035284-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| EP-0766670-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| US-6297264-B1 | E.G., 4-(2-BENZYLOXY-2-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)ETHYL)PYRID INE; PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |
| EP-0766670-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035284-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |