Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738939 | 1.00 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL738938 | 1.00 | HRH1 (0.45) | HRH1KCNH2CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL740732 | 0.94 | ADORA2A (0.44) | HRH1KCNH2CYP2D6CHRM1ADORA2A | |
| SCHEMBL740733 | 0.94 | ADORA2A (0.44) | HRH1KCNH2CYP2D6CHRM1ADORA2A | |
| SCHEMBL740731 | 0.94 | ADORA2A (0.44) | HRH1KCNH2CYP2D6CHRM1ADORA2A | |
| SCHEMBL739089 | 0.94 | HRH1 (0.47) | HRH1KCNH2CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL739088 | 0.94 | HRH1 (0.47) | HRH1KCNH2CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL739087 | 0.94 | HRH1 (0.47) | HRH1KCNH2CYP2D6CHRM1ALDH1A1 | |
| SCHEMBL740677 | 0.92 | KCNH2 (0.46) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL740676 | 0.92 | KCNH2 (0.46) | HRH1KCNH2CYP2D6CHRM1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |