Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389213 | 0.87 | NPC1 (0.54) | HTR1ADRD3DRD2HTR2AHTR7 | |
| SCHEMBL7391420 | 0.86 | KMT2A (0.55) | HTR1ADRD3DRD2HTR2ATSHR | |
| SCHEMBL7381746 | 0.86 | TSHR (0.64) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7394120 | 0.86 | DRD2 (0.53) | HTR1ADRD3DRD2DRD4TSHR | |
| SCHEMBL7391863 | 0.86 | DRD2 (0.60) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7395417 | 0.86 | DRD2 (0.60) | HTR1ADRD3DRD2HTR2AHTR2C | |
| SCHEMBL7386508 | 0.85 | MAPT (0.61) | HTR1ADRD3DRD2HTR2AHTR7 | |
| SCHEMBL7390501 | 0.85 | MAPT (0.61) | HTR1ADRD3DRD2HTR2AHTR7 | |
| SCHEMBL7390493 | 0.85 | MAPT (0.61) | HTR1ADRD3DRD2HTR2AHTR7 | |
| SCHEMBL7392918 | 0.85 | NPC1 (0.56) | HTR1ADRD3DRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864039-A | THERAPEUTIC TREATMENT OF VARIOUS GASTROINTESTINAL DISEASES, CENTRAL NERVOUS DISORDERS, CARDIOVASCULAR DISORDERS, URINARY DISEASES, UROGENITAL DISORDERS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0873990-A1 | BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-10-28 | — | — | EP | disclosed |