Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.49 |
| ▸ | GABRD | O14764 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.49 |
| ▸ | GABRE | P78334 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391845 | 0.99 | GABRG2 (0.50) | GABRG2GABRB3GABRA5MEN1GABRP | |
| Hydrochloric Acid SCHEMBL8872348 | 0.98 | GABRG2 (0.49) | GABRG2GABRB3GABRA5MEN1GABRP | |
| Hydrochloric Acid SCHEMBL7391513 | 0.93 | GABRG2 (0.47) | GABRG2GABRB3GABRA5MEN1GABRP | |
| SCHEMBL7396501 | 0.91 | GABRG2 (0.51) | GABRG2GABRB3GABRA5MEN1GABRP | |
| Hydrochloric Acid SCHEMBL7396734 | 0.90 | GABRG2 (0.50) | GABRG2GABRB3GABRA5MEN1GABRP | |
| SCHEMBL7386504 | 0.88 | — | — | |
| SCHEMBL7396066 | 0.88 | GABRG2 (0.52) | GABRG2GABRB3GABRA5MEN1GABRP | |
| SCHEMBL7384812 | 0.88 | GABRG2 (0.52) | GABRG2GABRB3GABRA5MEN1GABRP | |
| SCHEMBL7392604 | 0.88 | — | — | |
| SCHEMBL7392325 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672666-A2 | Imidazodiazepins | F. Hoffmann-La Roche AG (CH) | 1995-09-20 | — | — | EP | claimed |
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0672666-A2 | Imidazodiazepins | F. Hoffmann-La Roche AG (CH) | 1995-09-20 | — | — | EP | disclosed |