Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739174 | 1.00 | HRH1 (0.47) | HRH1HTR2BKCNH2PTGER4CYP2D6 | |
| SCHEMBL741193 | 0.92 | HRH1 (0.46) | HRH1KCNH2CYP2D6PIK3CDPIK3CB | |
| SCHEMBL741194 | 0.92 | HRH1 (0.46) | HRH1KCNH2CYP2D6PIK3CDPIK3CB | |
| SCHEMBL740879 | 0.91 | HTR2B (0.43) | HRH1HTR2BKCNH2CYP2D6PROKR1 | |
| SCHEMBL740878 | 0.91 | HTR2B (0.43) | HRH1HTR2BKCNH2CYP2D6PROKR1 | |
| SCHEMBL738819 | 0.90 | HRH1 (0.43) | HRH1HTR2BKCNH2CYP2D6CHRM1 | |
| SCHEMBL738820 | 0.90 | HRH1 (0.43) | HRH1HTR2BKCNH2CYP2D6CHRM1 | |
| SCHEMBL738739 | 0.90 | HRH1 (0.46) | HRH1HTR2BKCNH2CYP2D6CHRM1 | |
| SCHEMBL738740 | 0.90 | HRH1 (0.46) | HRH1HTR2BKCNH2CYP2D6CHRM1 | |
| SCHEMBL740626 | 0.90 | HRH1 (0.42) | HRH1HTR2BKCNH2CYP2D6PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |