Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 11/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739285 | 1.00 | HDAC2 (0.60) | HDAC2HDAC1HDAC3NTRK1SMN1; SMN2 | |
| SCHEMBL763205 | 0.92 | HDAC2 (0.53) | HDAC2HDAC1HDAC3NTRK1SMN1; SMN2 | |
| SCHEMBL17533942 | 0.85 | HDAC1 (0.62) | HDAC2HDAC1HDAC3SMN1; SMN2ABL1 | |
| SCHEMBL762580 | 0.85 | HDAC1 (0.62) | HDAC2HDAC1HDAC3SMN1; SMN2ABL1 | |
| SCHEMBL19378084 | 0.85 | HDAC1 (0.62) | HDAC2HDAC1HDAC3SMN1; SMN2ABL1 | |
| SCHEMBL193295 | 0.83 | RAB9A (0.65) | HDAC2HDAC1ABL1RIN1RAB9A | |
| SCHEMBL193294 | 0.83 | RAB9A (0.65) | HDAC2HDAC1ABL1RIN1RAB9A | |
| SCHEMBL5871130 | 0.81 | KMT2A (0.60) | SMN1; SMN2ABL1RIN1GAARAB9A | |
| SCHEMBL18051102 | 0.80 | PARP1 (0.47) | HDAC2HDAC1NTRK1ABL1RIN1 | |
| SCHEMBL29842154 | 0.80 | PARP1 (0.47) | HDAC2HDAC1NTRK1ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |