Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546601 | 0.81 | CHRNB2 (0.39) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL1546602 | 0.81 | CHRNB2 (0.39) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL30275098 | 0.81 | CHRNB2 (0.39) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL31257124 | 0.81 | PARP1 (0.37) | HRH3PARP1CASP3MAPK1 | |
| SCHEMBL6965933 | 0.81 | PARP1 (0.32) | HRH3PARP1CASP3 | |
| SCHEMBL376484 | 0.81 | PARP1 (0.37) | HRH3PARP1CASP3MAPK1 | |
| SCHEMBL2584375 | 0.81 | PARP1 (0.44) | PARP1USP2SMN1; SMN2MAPK1 | |
| SCHEMBL18673224 | 0.81 | PARP1 (0.44) | PARP1USP2SMN1; SMN2MAPK1 | |
| SCHEMBL5389458 | 0.80 | PARP1 (0.33) | HRH3PARP1 | |
| SCHEMBL27286359 | 0.80 | CHRNB2 (0.33) | MMP1MMP3MMP7MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581789-A1 | NOVEL 2-SPIROCYCLOPROPYL CEPHALOSPORIN SULFONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | SYNPHAR LABORATORIES INC. (CA) | 1994-02-09 | — | — | EP | disclosed |
| US-5264430-A | Enzyme inhibitor, antiinflammatory agents, treats emphysema, cystic fibrosis and arthritis | SYNPHAR LABORATORIES, INC. (CA) | 1993-11-23 | — | — | US | disclosed |
| US-5264429-A | Enzyme inhibitor, antiinflammatory agents, treats emphysema, cystic fibrosis and arthritis | SYNPHAR LABORATORIES, INC. (CA) | 1993-11-23 | — | — | US | disclosed |
| WO-1992018474-A2 | NOVEL 2-SPIROCYCLOPROPYL CEPHALOSPORIN SULFONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | SYNPHAR LABORATORIES, INC. (CA) | 1992-10-29 | — | — | WO | disclosed |