Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 6/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739357 | 1.00 | CHRM1 (0.53) | CHRM1HRH1ADORA2ABRD4DRD2 | |
| SCHEMBL737976 | 0.86 | HRH1 (0.55) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL740755 | 0.86 | HRH1 (0.52) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL740756 | 0.86 | HRH1 (0.52) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL742773 | 0.86 | HRH1 (0.54) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL737977 | 0.86 | HRH1 (0.55) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL742774 | 0.86 | HRH1 (0.54) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL739843 | 0.84 | HRH1 (0.70) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL739842 | 0.84 | HRH1 (0.70) | CHRM1HRH1BRD4RENOPRM1 | |
| SCHEMBL740511 | 0.82 | CHRM1 (0.48) | CHRM1HRH1ADORA2ABRD4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |