Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 6/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742774 | 1.00 | HRH1 (0.54) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL740741 | 0.92 | HRH1 (0.54) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL740742 | 0.92 | HRH1 (0.54) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL737977 | 0.88 | HRH1 (0.55) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL737976 | 0.88 | HRH1 (0.55) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL740755 | 0.88 | HRH1 (0.52) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL740756 | 0.88 | HRH1 (0.52) | HRH1CHRM1BRD4RENMAPT | |
| SCHEMBL739358 | 0.86 | CHRM1 (0.53) | HRH1CHRM1BRD4RENOPRM1 | |
| SCHEMBL739357 | 0.86 | CHRM1 (0.53) | HRH1CHRM1BRD4RENOPRM1 | |
| SCHEMBL739842 | 0.85 | HRH1 (0.70) | HRH1CHRM1BRD4RENOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |