SCHEMBL739381

SCHEMBL739381

C=C(c1ccccc1)c1ccc(C(C)(C)c2ccc(C(=C)c3ccccc3)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.54
ESR2 Q92731 4/20 0.54
CYP3A4 P08684 2/20 0.54
ALDH1A1 P00352 1/20 0.54
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 2/20 0.44
ESRRG P62508 2/20 0.44
AR P10275 1/20 0.44
HPGD P15428 1/20 0.44
TSHR P16473 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
HTR6 P50406 1/20 0.44
SLC6A3 Q01959 1/20 0.44
MAPT P10636 2/20 0.41
HTT P42858 1/20 0.41
GFER P55789 1/20 0.41
GPR55 Q9Y2T6 1/20 0.41
NR3C2 P08235 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6547689 0.87 MEN1 (0.53) ALDH1A1MEN1KMT2AESRRGMAPT
SCHEMBL16034288 0.83 KMT2A (0.50) ESR1ESR2CYP3A4ALDH1A1MEN1
SCHEMBL7787065 0.83 TSHR (0.46) ESR1ESR2CYP3A4ALDH1A1HSD17B10
SCHEMBL894135 0.81 MEN1 (0.65) CYP3A4ALDH1A1MEN1KMT2AHSD17B10
SCHEMBL16032966 0.80 KMT2A (0.47) ESR1ESR2CYP3A4ALDH1A1MEN1
SCHEMBL10599702 0.80 MEN1 (0.47) MEN1KMT2AHSD17B10MAPTHTT
SCHEMBL14067809 0.79 ESR1 (0.50) ESR1ESR2CYP3A4ALDH1A1HSD17B10
SCHEMBL7787068 0.79 SMN1; SMN2 (0.41) ESR1ESR2CYP3A4ALDH1A1MEN1
SCHEMBL11420172 0.78 ALDH1A1 (0.61) ESR1ESR2CYP3A4ALDH1A1MEN1
SCHEMBL28668106 0.78 ALDH1A1 (0.54) ALDH1A1MEN1KMT2ATSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825199-B1 mediated by transition metal complex in redox reaction of atom transfer Atom Transfer Coupling Reaction to/from initiator or dormant polymer and growing active polymer chain ends; transition metal held in close conjunction with a solid support; salt containing a soluble organic counterion; styrene graft CARNEGIE MELLON UNIVERSITY (US) 2010-11-02 US claimed
US-20040171779-A1 Redox systems; using transition metal complex catalysts; atom transfer radical polymerization CARNEGIE MELLON UNIVERSITY (A NON-PROFIT PENNSYLVANIA ORGANIZATION) 2004-09-02 US claimed
EP-1171496-A1 CATALYTIC PROCESSES FOR THE CONTROLLED POLYMERIZATION OF FREE RADICALLY (CO)POLYMERIZABLE MONOMERS AND FUNCTIONAL POLYMERIC SYSTEMS PREPARED THEREBY CARNEGIE-MELLON UNIVERSITY (US) 2002-01-16 EP claimed
WO-2000056795-A1 CATALYTIC PROCESSES FOR THE CONTROLLED POLYMERIZATION OF FREE RADICALLY (CO)POLYMERIZABLE MONOMERS AND FUNCTIONAL POLYMERIC SYSTEMS PREPARED THEREBY CARNEGIE MELLON UNIVERSITY (US) 2000-09-28 WO claimed
EP-1637550-B1 Catalytic processes for the controlled polymerization of free radically (co) polymerizable monomers and functional polymeric systems prepared thereby UNIV CARNEGIE MELLON (US) 2017-09-20 EP disclosed
WO-2015145175-A1 POLYMER, METHOD OF MAKING A POLYMER AND USES OF SAID POLYMER SYNTHOMER (UK) LIMITED (GB) 2015-10-01 WO disclosed
US-8137860-B2 Polymer electrolyte membrane for solid polymer fuel cell, membrane-electrode assembly and fuel cell KURARAY CO., LTD. (JP) 2012-03-20 US disclosed
EP-1852928-B1 ION-CONDUCTIVE BINDER, MEMBRANE-ELECTRODE ASSEMBLY AND FUEL CELL KURARAY CO LTD KURASHIKI PLANT (JP) 2011-11-16 EP disclosed
US-20110265032-A1 DISPLAY OF FILTERED DATA VIA ORDERED VALUES MICROSOFT CORPORATION (US) 2011-10-27 US disclosed
US-7825199-B1 mediated by transition metal complex in redox reaction of atom transfer Atom Transfer Coupling Reaction to/from initiator or dormant polymer and growing active polymer chain ends; transition metal held in close conjunction with a solid support; salt containing a soluble organic counterion; styrene graft CARNEGIE MELLON UNIVERSITY (US) 2010-11-02 US disclosed
US-20100233569-A1 ELECTROLYTE MULTILAYER MEMBRANE FOR SOLID POLYMER FUEL CELL, MEMBRANE-ELECTRODE ASSEMBLY, AND FUEL CELL KURARAY CO., LTD (JP) 2010-09-16 US disclosed
US-7740968-B2 Ion-conductive binder membrane-electrode assembly and fuel cell KURARAY CO., LTD. (JP) 2010-06-22 US disclosed
WO-2000032609-A1 SILYL-FUNCTIONAL INITIATOR FOR LIVING CATIONIC POLYMERIZATION DOW CORNING CORPORATION (US) 2000-06-08 WO disclosed
US-6051657-A Silyl-functional living cationic polymers DOW CORNING ASIA, LTD. (JP) 2000-04-18 US disclosed
US-6046281-A REACTING A LIVING CATIONIC POLYMER WITH AN ORGANIC COMPOUND HAVING AT LEAST 2 FURAN RINGS IN ITS MOLECULE, SUCH AS DIFURANYLHEXANE IN THE PRESENCE OF A LEWIS ACID UNIVERSITY OF MASSACHUSETTS LOWELL (US) 2000-04-04 US disclosed
US-5981785-A Silyl-functional initiator for living cationic polymerization UNIVERSITY OF MASSACHUSETTS (US) 1999-11-09 US disclosed
WO-1999024480-A1 METHOD FOR COUPLING LIVING CATIONIC POLYMERS DOW CORNING CORPORATION (US) 1999-05-20 WO disclosed
US-4205016-A Multifunctional lithium containing initiator THE DOW CHEMICAL COMPANY (US) 1980-05-27 US disclosed
US-4201729-A CONTAINING BUTADIENE AND/OR ISOPRENE UNITS THE DOW CHEMICAL COMPANY (US) 1980-05-06 US disclosed
US-4200718-A Multifunctional lithium containing initiator THE DOW CHEMICAL COMPANY (US) 1980-04-29 US disclosed