Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739446 | 1.00 | KCNH2 (0.42) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL739447 | 1.00 | KCNH2 (0.42) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL741888 | 0.94 | OPRK1 (0.44) | KCNH2HRH1CYP2D6CHRM1OPRK1 | |
| SCHEMBL741887 | 0.94 | OPRK1 (0.44) | KCNH2HRH1CYP2D6CHRM1OPRK1 | |
| SCHEMBL740677 | 0.94 | KCNH2 (0.46) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL740676 | 0.94 | KCNH2 (0.46) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL740675 | 0.94 | KCNH2 (0.46) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL738808 | 0.93 | HRH1 (0.44) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL739789 | 0.93 | KCNH2 (0.47) | KCNH2HRH1CYP2D6CHRM1TP53 | |
| SCHEMBL739790 | 0.93 | KCNH2 (0.47) | KCNH2HRH1CYP2D6CHRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |