Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391819 | 0.84 | TRPV1 (0.44) | RETRAF1 | |
| SCHEMBL7393573 | 0.84 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7395341 | 0.84 | RET (0.45) | RETALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL7394146 | 0.81 | PANK3 (0.42) | RETRAF1CNR1CNR2 | |
| SCHEMBL20069375 | 0.80 | RET (0.47) | RETHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29686486 | 0.80 | RET (0.47) | RETHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28704572 | 0.80 | RET (0.45) | RETHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30531745 | 0.80 | RET (0.45) | RETHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30531761 | 0.80 | RET (0.45) | RETCKS1BSKP1SKP2RAF1 | |
| SCHEMBL18291254 | 0.79 | RET (0.45) | RETMEN1KMT2ARAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723611-A | Heteroarylpiperidines | SANOFI (FR) | 1998-03-03 | — | — | US | disclosed |
| US-5595994-A | 1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1997-01-21 | — | — | US | disclosed |
| US-5502063-A | 1-halopyridin-4-amino-4-alkylpiperidines | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| EP-0647639-A1 | Heteroarylpiperidines, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |