Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060135 | 1.00 | TSHR (0.61) | TSHRHSD17B10CA2CYP11B1CYP11B2 | |
| SCHEMBL2959480 | 0.98 | TSHR (0.58) | TSHRHSD17B10CA2CYP11B1CYP11B2 | |
| SCHEMBL81846 | 0.92 | TSHR (0.55) | TSHRHSD17B10CA2CYP11B1CYP11B2 | |
| SCHEMBL16582531 | 0.89 | TSHR (0.71) | TSHRHSD17B10CA2KCNJ1KCNH2 | |
| SCHEMBL10569117 | 0.89 | TSHR (0.71) | TSHRHSD17B10CA2KCNJ1KCNH2 | |
| SCHEMBL16582463 | 0.89 | TSHR (0.71) | TSHRHSD17B10CA2KCNJ1KCNH2 | |
| SCHEMBL10569888 | 0.87 | TSHR (0.68) | TSHRHSD17B10CA2KCNJ1KCNH2 | |
| SCHEMBL10773059 | 0.86 | TSHR (0.64) | TSHRHSD17B10CA2CYP11B1CYP11B2 | |
| SCHEMBL7030337 | 0.85 | TSHR (0.46) | TSHRHSD17B10CA2CYP11B1CYP11B2 | |
| SCHEMBL16603419 | 0.83 | TSHR (0.82) | TSHRHSD17B10CA2KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646183-A | Phenyl amidine alkanoic acids useful as platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5612355-A | Phenyl amidine lactones useful as platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1997-03-18 | — | — | US | disclosed |
| US-5504106-A | Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |
| WO-1994000424-A1 | PHENYL AMIDINE ALKANOIC ACIDS AND LACTONES USEFUL AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-01-06 | — | — | WO | disclosed |