Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 20/20 | 0.74 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7394634 | 0.94 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7395333 | 0.92 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7394778 | 0.91 | HTR4 (0.77) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7392734 | 0.91 | HTR4 (0.77) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7393972 | 0.90 | HTR4 (0.75) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL8056984 | 0.89 | HTR4 (0.80) | HTR4HTR2AKCNH2 | |
| SCHEMBL9055122 | 0.89 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7397043 | 0.89 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| SCHEMBL7391493 | 0.89 | HTR4 (0.65) | HTR4HTR2AKCNH2 | |
| SCHEMBL7395608 | 0.88 | HTR4 (0.72) | HTR4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732333-B1 | Indazolecarboxamides | LILLY CO ELI (US) | 2001-08-01 | — | — | EP | disclosed |
| US-5817676-A | 5-HT4 RECEPTOR ANTAGONISTS, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| US-5798367-A | ANTAGONIZE 5-HYDROXYTRYPTAMINE RECEPTOR IN GASTROINTESTINAL TRACT OR GENITOURINARY TRACT | ELI LILLY AND COMPANY (US) | 1998-08-25 | — | — | US | disclosed |
| US-5654320-A | SEROTONIN RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033713-A1 | INDAZOLECARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0732333-A1 | Indazolecarboxamides | ELI LILLY AND COMPANY (US) | 1996-09-18 | — | — | EP | disclosed |