Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392578 | 0.86 | MAOA (0.50) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL6709201 | 0.82 | CCNB2 (0.52) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL30428749 | 0.82 | CCNB2 (0.52) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL7395874 | 0.78 | MAOB (0.50) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL865350 | 0.76 | MAOA (0.58) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL3615463 | 0.76 | MAOB (0.58) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL23796751 | 0.75 | MAOB (0.57) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL6409166 | 0.75 | BCHE (0.51) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL6629023 | 0.75 | BCHE (0.51) | MAOAMAOBCCNB2CDK1CDK4 | |
| SCHEMBL28671704 | 0.74 | MEN1 (0.48) | MAOAMAOBCCNB2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0807621-A1 | Derivatives of phenylglycine and use thereof as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |