Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | FLT3 | P36888 | 6/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742313 | 0.92 | ABL1 (0.51) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL743001 | 0.91 | ABL1 (0.51) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL743719 | 0.89 | ABL1 (0.55) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL740292 | 0.89 | AURKA (0.55) | ABL1BCRAURKAHDAC6IMPDH2 | |
| SCHEMBL741926 | 0.88 | AURKA (0.52) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL2432388 | 0.87 | FLT3 (0.47) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL739415 | 0.86 | ABL1 (0.53) | ABL1BCRAURKAFLT3KIT | |
| SCHEMBL738866 | 0.86 | AURKA (0.53) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL741311 | 0.86 | AURKA (0.53) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL741133 | 0.86 | ABL1 (0.54) | ABL1BCRAURKAFLT3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | disclosed |