Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 7/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | KLK1 | P06870 | 2/20 | 0.37 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740292 | 0.91 | AURKA (0.55) | ABL1BCRAURKAHDAC6IMPDH2 | |
| SCHEMBL739669 | 0.89 | ABL1 (0.53) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL738866 | 0.88 | AURKA (0.53) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL741311 | 0.88 | AURKA (0.53) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL741133 | 0.88 | ABL1 (0.54) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL743001 | 0.87 | ABL1 (0.51) | ABL1BCRAURKAFLT3HDAC6 | |
| SCHEMBL740809 | 0.87 | AURKA (0.52) | ABL1BCRAURKAHDAC6IMPDH2 | |
| SCHEMBL742638 | 0.86 | ABL1 (0.74) | ABL1BCRAURKAFLT3FGFR1 | |
| SCHEMBL739415 | 0.86 | ABL1 (0.53) | ABL1BCRAURKAFLT3HDAC1 | |
| SCHEMBL740623 | 0.86 | ABL1 (0.72) | ABL1BCRAURKAFLT3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |