Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34463390 | 1.00 | NOTUM (0.56) | NOTUMHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL7379739 | 0.82 | NOTUM (0.62) | NOTUMHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL31534621 | 0.77 | MCL1 (0.37) | NOTUMALDH1A1KMT2A | |
| SCHEMBL28738203 | 0.77 | NOTUM (0.44) | NOTUMHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL29625268 | 0.77 | NOTUM (0.44) | NOTUMHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL31534612 | 0.77 | AHR (0.34) | NOTUMALDH1A1MAPTKMT2A | |
| SCHEMBL4879783 | 0.74 | HTR2A (0.53) | NOTUMHTR2AHTR2CZAP70HTR1A | |
| SCHEMBL31534602 | 0.73 | PARP1 (0.38) | KDM4ELMNA | |
| SCHEMBL30615209 | 0.72 | NOTUM (1.00) | NOTUMHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL9259627 | 0.72 | NOTUM (1.00) | NOTUMHTR2AHTR2CALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113583000-A | Method for preparing imidazo [1,5-a ] indol-3-one | 成都大学 | 2021-11-02 | — | — | CN | disclosed |
| EP-0711293-B1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZO[1,5-a]INDOL-3-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2000-07-05 | — | — | EP | disclosed |
| US-5874457-A | 5-HT ANTAGONISTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-23 | — | — | US | disclosed |
| EP-0711293-A1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZO(1,5-A)INDOL-3-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| EP-0711299-A1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT 3 ANTAGONISTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995032204-A1 | IMIDAZOLYLALKYL DERIVATIVES OF IMIDAZO(1,5-A)INDOL-3-ONE AND THEIR USE AS THERAPEUTIC AGENTS | PHARMACIA S.P.A. (IT) | 1995-11-30 | — | — | WO | disclosed |
| WO-1995032209-A1 | AZABICYCLOALKYL DERIVATIVES OF IMIDAZO(1,5-a)INDOL-3-ONE AS 5HT3 ANTAGONISTS | PHARMACIA S.P.A. (IT) | 1995-11-30 | — | — | WO | disclosed |