Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17038980 | 0.83 | MAPT (0.31) | ALDH1A1MAPTMMP1MMP2MMP3 | |
| SCHEMBL23098246 | 0.83 | MAPT (0.31) | ALDH1A1MAPTMMP1MMP2MMP3 | |
| SCHEMBL17038909 | 0.83 | MAPT (0.31) | ALDH1A1MAPTMMP1MMP2MMP3 | |
| SCHEMBL9659071 | 0.81 | ALDH1A1 (0.36) | TSHRALDH1A1NAALAD2HTTMEN1 | |
| SCHEMBL23098247 | 0.81 | HTT (0.38) | HTT | |
| SCHEMBL3485811 | 0.79 | NAALAD2 (0.41) | TSHRALDH1A1NAALAD2HTTMEN1 | |
| SCHEMBL18673261 | 0.78 | ABCC4 (0.39) | TSHRALDH1A1NAALAD2MAPT | |
| SCHEMBL24633782 | 0.76 | ALDH1A1 (0.37) | TSHRALDH1A1NAALAD2HTTMEN1 | |
| SCHEMBL24633938 | 0.76 | ALDH1A1 (0.37) | TSHRALDH1A1NAALAD2HTTMEN1 | |
| Boric Acid SCHEMBL29152969 | 0.75 | NAALAD2 (0.34) | TSHRALDH1A1NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |