SCHEMBL7398152

SCHEMBL7398152

COc1ccc2c(O)cc(-c3nc(C)c[nH]3)nc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.41
ALDH1A1 P00352 4/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
MPO P05164 1/20 0.40
TLR8 Q9NR97 1/20 0.38
ADORA2A P29274 1/20 0.37
TACR3 P29371 4/20 0.37
STAT3 P40763 1/20 0.37
HPGD P15428 3/20 0.36
HSD17B10 Q99714 2/20 0.36
POLB P06746 1/20 0.36
GUSB P08236 1/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
DYRK1A Q13627 1/20 0.36
TSHR P16473 1/20 0.35
HBB P68871 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7396607 0.80 SMPD3 (0.42) KDM4EALDH1A1SMN1; SMN2MPOTLR8
SCHEMBL8139912 0.77 NPSR1 (0.54) KDM4EALDH1A1SMN1; SMN2NPSR1MPO
SCHEMBL7396622 0.77 MPO (0.42) KDM4EALDH1A1SMN1; SMN2NPSR1MPO
SCHEMBL31429628 0.76 MGAM (0.52) KDM4ESMN1; SMN2NPSR1ADORA2AGAA
SCHEMBL12732312 0.76 KDM4E (0.58) KDM4EALDH1A1SMN1; SMN2NPSR1TACR3
SCHEMBL6809754 0.76 KDM4E (0.46) KDM4EALDH1A1SMN1; SMN2NPSR1MPO
SCHEMBL8161422 0.76 RAC1 (0.52) KDM4EALDH1A1SMN1; SMN2NPSR1TLR8
SCHEMBL8139843 0.75 ACP1 (0.43) KDM4EALDH1A1SMN1; SMN2NPSR1MPO
SCHEMBL7396057 0.75 SMN1; SMN2 (0.45) KDM4EALDH1A1SMN1; SMN2NPSR1MPO
SCHEMBL31429583 0.75 GAA (0.53) KDM4EALDH1A1SMN1; SMN2NPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1169339-A1 MACROCYCLIC PEPTIDES INHIBITING THE HEPATITIS C VIRUS NS3 PROTEASE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2002-01-09 EP disclosed
WO-2000059929-A1 MACROCYCLIC PEPTIDES ACTIVE AGAINST THE HEPATITIS C VIRUS BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2000-10-12 WO disclosed