Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KHK | P50053 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074672 | 0.88 | ADRB1 (0.76) | MAPTNPC1ADRB1KDM4EGFER | |
| SCHEMBL19212406 | 0.86 | ADRB1 (0.69) | MAPTNPC1ADRB1KDM4EDRD2 | |
| SCHEMBL27371785 | 0.84 | KDM4E (0.75) | MAPTNPC1KDM4EGFERDRD2 | |
| SCHEMBL8890453 | 0.82 | GAA (0.69) | MAPTNPC1ADRB1DRD2ALDH1A1 | |
| SCHEMBL1372927 | 0.81 | KCNH2 (0.69) | MAPTNPC1ADRB1KDM4EDRD2 | |
| SCHEMBL23675047 | 0.80 | ADRB1 (0.71) | MAPTNPC1ADRB1KDM4EDRD2 | |
| SCHEMBL3051915 | 0.80 | ADRB1 (0.71) | MAPTNPC1ADRB1KDM4EDRD2 | |
| SCHEMBL30255158 | 0.80 | ADRB1 (0.71) | MAPTNPC1ADRB1KDM4EDRD2 | |
| SCHEMBL12526595 | 0.80 | AOC3 (0.53) | MAPTNPC1KDM4EGFERDRD2 | |
| SCHEMBL1365556 | 0.79 | ADRB1 (0.65) | MAPTNPC1ADRB1KDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563141-A | INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| EP-0690847-A1 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994022835-A2 | HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | ZENECA LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |