Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRE | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17163990 | 0.86 | POLB (0.71) | POLBALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL11607443 | 0.82 | ALDH1A1 (0.59) | POLBMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8248507 | 0.81 | ALDH1A1 (0.42) | POLBMAPK1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2128678 | 0.79 | ALDH1A1 (0.56) | POLBMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL31199000 | 0.79 | ALDH1A1 (0.56) | POLBMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20454667 | 0.77 | ALDH1A1 (0.67) | POLBMAPK1ALDH1A1SMN1; SMN2GABRP | |
| SCHEMBL2097253 | 0.76 | POLB (0.45) | POLBMAPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL25331044 | 0.72 | POLB (0.57) | POLBMAPK1ALDH1A1SMN1; SMN2KDM4E | |
| Nitrous Acid SCHEMBL28169416 | 0.72 | ALDH1A1 (0.47) | POLBMAPK1ALDH1A1SMN1; SMN2GABRP | |
| SCHEMBL27611644 | 0.71 | ALDH1A1 (0.46) | POLBMAPK1ALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696129-A | TREATING GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-09 | — | — | US | disclosed |
| EP-0662959-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-07-19 | — | — | EP | disclosed |
| EP-0611370-A1 | PYRIDINE-3-CARBOXYLIC ACID ESTERS OR AMIDES USEFUL AS 5-HT 3? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-08-24 | — | — | EP | disclosed |
| WO-1994007859-A1 | 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-14 | — | — | WO | disclosed |
| WO-1993008186-A1 | PYRIDINE-3-CARBOXYLIC ACID ESTERS OR AMIDES USEFUL AS 5-HT3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-04-29 | — | — | WO | disclosed |