Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 15/20 | 0.54 |
| ▸ | ITGAV | P06756 | 3/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396677 | 0.86 | ITGB3 (0.71) | ITGB3ITGA2BITGAV | |
| SCHEMBL7433066 | 0.84 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL7433059 | 0.84 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL7398292 | 0.84 | ITGB3 (0.52) | ITGB3ITGA2BITGAVBRD4HDAC1 | |
| SCHEMBL7445083 | 0.84 | ITGB3 (0.48) | ITGB3ITGA2BITGAV | |
| SCHEMBL7398371 | 0.82 | ITGB3 (0.48) | ITGB3ITGA2BITGAVKDM1ARCOR1 | |
| SCHEMBL7396914 | 0.81 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL7396908 | 0.81 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL7396683 | 0.80 | ITGB3 (0.55) | ITGB3ITGA2BITGAVBRD4HDAC1 | |
| SCHEMBL7401120 | 0.78 | ITGB3 (0.58) | ITGB3ITGA2BITGAVFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593603-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6127359-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0593603-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-04-27 | — | — | EP | disclosed |
| WO-1993000095-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-07 | — | — | WO | disclosed |