Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 16/20 | 0.72 |
| ▸ | AGTR2 | P50052 | 16/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395945 | 0.93 | AGTR1 (0.75) | AGTR1AGTR2 | |
| SCHEMBL7833154 | 0.92 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL9143472 | 0.92 | AGTR1 (0.68) | AGTR1AGTR2 | |
| SCHEMBL9033077 | 0.91 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL7830103 | 0.91 | AGTR1 (0.70) | AGTR1AGTR2 | |
| SCHEMBL7398420 | 0.91 | AGTR1 (0.74) | AGTR1AGTR2 | |
| SCHEMBL7398430 | 0.91 | AGTR1 (0.74) | AGTR1AGTR2 | |
| SCHEMBL9032389 | 0.90 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL7827242 | 0.90 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL7398914 | 0.90 | AGTR1 (0.71) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | claimed |
| WO-1991018888-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-12 | — | — | WO | claimed |
| EP-0412594-B1 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO INC (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991018888-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-12 | — | — | WO | disclosed |
| EP-0412594-A2 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-02-13 | — | — | EP | disclosed |