Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28277578 | 0.93 | MEN1 (0.41) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL28277576 | 0.93 | MEN1 (0.41) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL16394247 | 0.87 | MEN1 (0.42) | MEN1GAAKMT2ATDP1CA2 | |
| SCHEMBL16394248 | 0.87 | MEN1 (0.42) | MEN1GAAKMT2ATDP1CA2 | |
| SCHEMBL3180767 | 0.81 | DGAT1 (0.47) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL3936414 | 0.81 | DGAT1 (0.47) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL4549806 | 0.81 | DGAT1 (0.47) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL31239054 | 0.81 | DGAT1 (0.40) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL28682013 | 0.79 | DGAT1 (0.45) | DGAT1MEN1GAAKMT2ATDP1 | |
| SCHEMBL28682014 | 0.79 | DGAT1 (0.45) | DGAT1MEN1GAAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183238-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069816-A1 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-11-23 | — | — | WO | disclosed |